Dr. Imran Naseer joined the CEGMR as a neuroscientist from Gyeongsang National University, South Korea. His area of expertise fall in Human molecular genetics, cellular and developmental neuroscience. His PhD work was based on the effect of ethanol on siRNA-Mediated GABAB1 receptor expression for downstream signaling pathways, apoptotic neurodegeneration, maternal epileptic seizure and role of GABABR1 receptor expression in early development of pre and postnatal rat brain.

Currently he is involved in neurogenetic research program at CEGMR, working on common neurologic disorders including Progressive Myoclonic, Juvenile Myoclonic, Idiopathic Generalized Epilepsy, Autism, Mental retardation, Microcephaly and other neurodegenerative and neurodevelopmental disorders of Saudi Arabia using microarray platform for array CGH, CNV/SNP analysis and Next generation technology for expression and whole exome / whole genome analysis. Dr. Imran has more than 12 years of research experience in Molecular biology techniques, Sanger Sequencing, high throughput sequencing for Whole exome and whole genome sequencing, array CGH analysis, real time RT PCR, molecular cloning, Western blot analysis, Cell biology, tissue culture, microscopy, flow cytometric analysis, Immunohistochemistry, Electron microscopy SEM, TEM, Confocal microscopy, animal models study, such as knock out, knock in mice model, primary, adult neuronal cell culturing and behavioral studies.

Dr_Muhammad_Imran

Further aim of the research is to find novel genes and mutations specially the role of different KIFs genes in neurodegenerative disorders in the Saudi Arabia including Epilepsy, Autism, Alzheimer's intellectual disabilities and mental retardations. In addition, Dr. Imran uses Knock-in/Knock-out animal models based on the identification of novel mutations/findings related to epileptic patients for known as well as novel genetic aberrations to utilize them for testing novel therapeutic agents in a targeted therapeutic approach for epilepsy and microcephaly.

Projects:

  1. Application of advanced high-density array technology for mutational analysis to detect genome-wide copy number variations and single nucleotide polymorphisms in Juvenile Myoclonic Epilepsy from Western Saudi Arabia (KACST Strategic Grants 12-BIO3059-03).
  2. Study of novel gene and mutations from primary Microcephaly in Saudi Arabia using advanced high-density array technology to detect genome-wide copy number variations and single nucleotide polymorphisms (KACST Large Grant APR 34-13).
  3. Comprehensive molecular analysis of Kinesin superfamily proteins (KIFs) and their role in neurodegenerative disease model in Saudi Arabia (HiCi Grant KAU).

Selected Publications:

  1. Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed H.Al-Qahtani, and Nobutaka Hirokawa. KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.. eLife Journal 2018 Jan 9;7. pii: e30935.
  2. Hussein Algahtani, Bader Shirah, Raghad Algahtani, Muhammad Imran Naseer, Mohammad H. Al-Qahtani, Angham Abdulrahman Abdulkareem. A Very Rare Form of Autosomal Dominant Progressive Myoclonus Epilepsy Caused by a Novel Variant in the PRICKLE1 Gene. Seizure: European Journal of Epilepsy 69 (2019) 133–139.
  3. Muhammad Imran Naseer, Mohammad Khalid Alwasiyah, Angham Abdulrahman Abdulkareem, et al. A novel homozygous mutation in SZT2 gene in Saudi family with developmental delay and epilepsy. (Genes and Genomics 40(11):1149-1155) 2018.
  4. Muhammad Imran Naseer *, Adeel G. Chaudhary, Sameera Sogaty, et al. Chromosomal micro-aberration in a Saudi family with Juvenile myoclonic epilepsy. (CNS Neurol Disord Drug Targets. 2017;16(9):1010-1017).
  5. Naseer MI, Sogaty S, Rasool M, Chaudhary AG, Abutalib YA, et al. Microcephaly-capillary malformation syndrome: Brothers with a homozygous STAMBP mutation, uncovered by exome sequencing. Am J Med Genet A. 2016 Aug 17.
  6. Muhammad Imran Naseer, Meena L Narasimhan, Ikram Ullah, Hae Young Lee, Irina Sokolchik, Ray A. Bressan, Dae-Jin Yun, and Myeong Ok Kim. Osmotin Protects Against Ethanol-Induced Apoptotic Neurodegeneration in the Developing Rat Brain. (Cell death and disease 2014 Mar 27;5:e1150).